%0 Journal Article
%T Non-compliance with IDSA guidelines for patients presenting with methicillin-susceptible Staphylococcus aureus prosthetic joint infection is a risk factor for treatment failure.
%A Bouaziz A
%A Uçkay I
%A Lustig S
%A Boibieux A
%A Lew D
%A Hoffmeyer P
%A Neyret P
%A Chidiac C
%A Ferry T
%J Med Mal Infect
%V 48
%N 3
%D May 2018
%M 29122410
%F 5.965
%R 10.1016/j.medmal.2017.09.016
%X <B>OBJECTIVE: </B>The long-term impact of treatment strategies proposed by the IDSA guidelines for patients presenting with methicillin-susceptible S. aureus (MSSA) prosthetic joint infection (PJI) is not well-known.<BR><B>METHODS: </B>Retrospective (2000-2010) cohort study including patients presenting with MSSA hip or knee PJI. A univariate Cox analysis was performed to determine if the non-compliance with IDSA surgical guidelines was a risk factor for treatment failure.<BR><B>RESULTS: </B>Eighty-nine patients with a mean follow-up of 2.8 years were included. Non-compliance with IDSA surgical guidelines was associated with treatment failure (hazard ratio 2.157; 95% CI [1.022-4.7]). The American Society of Anesthesiologists score, inadequate antimicrobial therapy, and a rifampicin-based regimen did not significantly influence patient outcome.<BR><B>CONCLUSIONS: </B>Based on the IDSA guidelines, if a patient presenting with MSSA PJI is not eligible for implant retention, complete implant removal is needed to limit treatment failure.