%0 Journal Article
%T Synthesis of piperazine sulfonamide analogs as diabetic-II inhibitors and their molecular docking study.
%A Taha M
%A Irshad M
%A Imran S
%A Chigurupati S
%A Selvaraj M
%A Rahim F
%A Ismail NH
%A Nawaz F
%A Khan KM
%J Eur J Med Chem
%V 141
%N 0
%D Dec 2017 1
%M 29102178
%F 7.088
%R 10.1016/j.ejmech.2017.10.028
%X Piperazine Sulfonamide analogs (1-19) have been synthesized, characterized by different spectroscopic techniques and evaluated for α-amylase Inhibition. Analogs 1-19 exhibited a varying degree of α-amylase inhibitory activity with IC50 values ranging in between 1.571 ± 0.05 to 3.98 ± 0.397 μM when compared with the standard acarbose (IC50 = 1.353 ± 0.232 μM). Compound 1, 2, 3 and 7 showed significant inhibitory effects with IC50 value 2.348 ± 0.444, 2.064 ± 0.04, 1.571 ± 0.05 and 2.118 ± 0.204 μM, respectively better than the rest of the series. Structure activity relationships were established. Molecular docking studies were performed to understand the binding interaction of the compounds.