%0 Journal Article
%T Serum concentrations of vitamin E and carotenoids are altered in Alzheimer's disease: A case-control study.
%A Mullan K
%A Williams MA
%A Cardwell CR
%A McGuinness B
%A Passmore P
%A Silvestri G
%A Woodside JV
%A McKay GJ
%J Alzheimers Dement (N Y)
%V 3
%N 3
%D Sep 2017
%M 29067349
暂无%R 10.1016/j.trci.2017.06.006
%X <B>BACKGROUND: </B>Oxidative stress has been implicated in the pathogenesis of Alzheimer's disease (AD). We investigated associations between serum levels of lipophilic antioxidants and AD.<BR><B>METHODS: </B>Serum concentrations of retinol, two forms of vitamin E (α- and γ-tocopherol) and six carotenoids were quantified by high-performance liquid chromatography from patients with AD (n = 251) and cognitively intact controls (n = 308) and assessed by regression analyses.<BR><B>RESULTS: </B>Serum levels of α-tocopherol and all six carotenoids were significantly lower in patients with AD compared with cognitively intact controls (P < .001). In contrast, γ-tocopherol was significantly higher in the serum of patients with AD (odds ratio = 1.17 [confidence intervals: 1.05-1.31]).<BR><B>CONCLUSIONS: </B>Our findings implicate compromised serum antioxidant defenses in AD pathogenesis and differing biological roles for vitamin E isoforms. This highlights the need for improved understanding in the balanced upregulation of exogenous antioxidants related to dietary intake or supplement use in future nutritional intervention studies.