%0 Clinical Trial
%T Pain during topical photodynamic therapy - comparing methyl aminolevulinate (Metvix®) to aminolaevulinic acid (Ameluz®); an intra-individual clinical study.
%A Yazdanyar S
%A Zarchi K
%A Jemec GBE
%J Photodiagnosis Photodyn Ther
%V 20
%N 0
%D Dec 2017
%M 28780136
%F 3.577
%R 10.1016/j.pdpdt.2017.07.010
%X <B>BACKGROUND: </B>Actinic keratoses are often treated by photodynamic therapy. However, the main side effect of this treatment is pain during and shortly after illumination.<BR><B>OBJECTIVE: </B>To evaluate, in an intra-individual study, whether the pain response differ in treatment of actinic keratoses in scalp and forhead, using branded methyl aminolevulinate (MAL) and aminolaevulinic acid (ALA).<BR><B>METHODS: </B>Patients with mild to moderate actinic keratoses on forehead and scalp were treated with methyl aminolaevulinate (MAL)-PDT and aminolaevulinic acid (ALA)-PDT on two similar areas of forehead and scalp. The pain response were measured using visual analogue scale ranging from 0 to 10 during the illumination and 30min after the treatment.<BR><B>RESULTS: </B>Fourteen patients completed treatment to MAL and ALA-PDT. We found no significant difference in pain intensity between MAL and ALA-PDT, neither during the treatment (p-value=1) nor 30min after the treatment (p-value of 0.19).<BR><B>CONCLUSIONS: </B>This intra-individual study demonstrate no significant difference between the pain response during PDT using methyl aminolevulinate and aminolaevulinic acid.