%0 Journal Article
%T Biodistribution and clearance of magnetoelectric nanoparticles for nanomedical applications using energy dispersive spectroscopy.
%A Hadjikhani A
%A Rodzinski A
%A Wang P
%A Nagesetti A
%A Guduru R
%A Liang P
%A Runowicz C
%A Shahbazmohamadi S
%A Khizroev S
%J Nanomedicine (Lond)
%V 12
%N 15
%D Aug 2017
%M 28705034
%F 6.096
%R 10.2217/nnm-2017-0080
%X <B>OBJECTIVE: </B>The biodistribution and clearance of magnetoelectric nanoparticles (MENs) in a mouse model was studied through electron energy dispersive spectroscopy.<BR><B>METHODS: </B>This approach allows for detection of nanoparticles (NPs) in tissues with the spatial resolution of scanning electron microscopy, does not require any tissue-sensitive staining and is not limited to MENs.<BR><B>RESULTS: </B>The size-dependent biodistribution of intravenously administrated MENs was measured in vital organs such as the kidneys, liver, spleen, lungs and brain at four different postinjection times including 1 day, 1 week, 4 and 8 weeks, respectively.<BR><B>CONCLUSIONS: </B>The smallest NPs, 10-nm MENs, were cleared relatively rapidly and uniformly across the organs, while the clearance of the larger NPs, 100- and 600-nm MENs, was highly nonlinear with time and nonuniform across the organs.