%0 Clinical Trial
%T Comparison of sequential vaginal and sublingual misoprostol after a vaginal loading dose for second-trimester abortion.
%A Huang MC
%A Hsieh CH
%A Huang JP
%A Tsai HT
%A Lee MS
%J Taiwan J Obstet Gynecol
%V 56
%N 3
%D Jun 2017
%M 28600039
%F 1.944
%R 10.1016/j.tjog.2017.04.008
%X <B>OBJECTIVE: </B>To evaluate the effects of sequential vaginal and sublingual misoprostol after a vaginal loading dose for second-trimester abortion.<BR><B>METHODS: </B>From January 2006 to December 2011, 173 women received an 800-μg vaginal loading dose of misoprostol. After the loading dose, 103 patients received 800 mg of misoprostol vaginally and 70 patients received 400 mg of misoprostol sublingually every 12 h until the delivery of the fetus.<BR><B>RESULTS: </B>In the vaginal group, the average abortion time was 1.07 ± 1.29 days; that was 0.82 ± 0.66 days in the sublingual group. Sequential sublingual misoprostol after a vaginal loading dose of 800 mg with an administration interval of 12 h had a similar abortion rate and time to abortion. In addition, this protocol reduced unnecessary digital pelvic examinations and speculum examinations.<BR><B>CONCLUSIONS: </B>This sequential sublingual misoprostol regimen might be a suitable regimen for mid-trimester abortion.