%0 Journal Article
%T Coexistence of KRAS and BRAF Mutations in Colorectal Cancer: A Case Report Supporting The Concept of Tumoral Heterogeneity.
%A Larki P
%A Gharib E
%A Yaghoob Taleghani M
%A Khorshidi F
%A Nazemalhosseini-Mojarad E
%A Asadzadeh Aghdaei H
%J Cell J
%V 19
%N 0
%D 2017
%M 28580315
%F 3.128
%R 10.22074/cellj.2017.5123
%X The detection of KRAS and BRAF mutations is a crucial step for the correct therapeutic approach and predicting the epidermal growth factor receptor (EGFR)-targeted therapy resistance of colorectal carcinomas. The concomitant KRAS and BRAF mutations occur rarely in the colorectal cancers (CRCs) with the prevalence of less than 0.001% of the cases. In patients with KRAS-mutant tumors, BRAF mutations should not regularly be tested unless the patient is participating in a clinical trial enriching for the presence of KRAS or BRAF-mutated tumor. The current report demonstrates a case with advanced adenocarcinoma of the colon showing the coexistence of KRAS and BRAF mutations and may have profound clinical implications for disease progression and therapeutic responses.