%0 Journal Article
%T Synthesis and in vitro investigation of potential antiproliferative monosaccharide-d-secoestrone bioconjugates.
%A Bodnár B
%A Mernyák E
%A Szabó J
%A Wölfling J
%A Schneider G
%A Zupkó I
%A Kupihár Z
%A Kovács L
%J Bioorg Med Chem Lett
%V 27
%N 9
%D 05 2017 1
%M 28343874
%F 2.94
%R 10.1016/j.bmcl.2017.03.029
%X The syntheses of monosaccharide-d-secoestrone conjugates are reported. They were prepared from 3-(prop-2-inyloxy)-d-secoestrone alcohol or oxime and monosaccharide azides via Cu(I)-catalyzed azide-alkyne cycloaddition reactions (CuAAC). The antiproliferative activities of the conjugates were investigated in vitro against a panel of human adherent cancer cell lines (HeLa, A2780 and MCF-7) by means of MTT assays. The protected d-glucose-containing d-secoestrone oxime bioconjugate (24b) proved to be the most effective with an IC50 value in the low micromolar range against A2780 cell line.