%0 Journal Article
%T Review of the role of probiotics in gastrointestinal diseases in adults.
%A Sebastián Domingo JJ
%J Gastroenterol Hepatol
%V 40
%N 6
%D Jun 2017 0
%M 28185664
%F 5.867
%R 10.1016/j.gastrohep.2016.12.003
%X <B>BACKGROUND: </B>Probiotics may act as biological agents that modify the intestinal microbiota and certain cytokine profiles, which can lead to an improvement in certain gastrointestinal diseases.<BR><B>OBJECTIVE: </B>To conduct a review of the evidence of the role of probiotics in certain gastrointestinal diseases in adults.<BR><B>METHODS: </B>Review conducted using appropriate descriptors, filters and limits in the PubMed database (MEDLINE).<BR><B>METHODS: </B>The MeSH terms used were Probiotics [in the title] AND Gastrointestinal Diseases, with the following limits or filters: Types of study: Systematic Reviews, Meta-Analysis, Guideline, Practice Guideline, Consensus Development Conference (and Consensus Development Conference NIH), Randomized Controlled Trial, Controlled Clinical Trial and Clinical Trial; age: adults (19 or older); language: English and Spanish; in humans, and with at least one abstract.<BR><B>METHODS: </B>Full texts of all the Systematic Reviews and meta-analyses directly related to the review's objective were obtained, as well as the Randomised Controlled Trials of the studies that were considered relevant and of sufficient quality for this review.<BR><B>RESULTS: </B>Certain probiotics, different for each process, have proven to be effective and beneficial in cases of acute infectious diarrhoea, antibiotic-associated diarrhoea, Clostridium difficile-associated diarrhoea, pouchitis and Helicobacter pylori infection eradication.<BR><B>CONCLUSIONS: </B>Although some probiotics have not demonstrated any benefit, there are certain gastrointestinal diseases in which the use of probiotics, true biological agents, can be recommended.