%0 Journal Article %T Prognostic value of the seventh AJCC/UICC TNM classification of intestinal-type ethmoid adenocarcinoma: Systematic review and risk prediction model. %A Fiaux-Camous D %A Chevret S %A Oker N %A Turri-Zanoni M %A Lombardi D %A Choussy O %A Duprez F %A Jorissen M %A de Gabory L %A Malard O %A Herman P %A Nicolai P %A Castelnuovo P %A Verillaud B %J Head Neck %V 39 %N 4 %D 04 2017 %M 28067974 %F 3.821 %R 10.1002/hed.24663 %X The purpose of this study was to propose a prognostic classification of intestinal-type adenocarcinoma (ITAC) based on literature search and prognostic modeling of cohort data.
We first conducted a literature search to assess the homogeneity of the reported estimates of 5-year survival and to identify the influence of T classification. We then pooled prospective data from 3 large French and Italian series to predict time to all-cause mortality. The sample was randomly split to derive and then to validate the proposed prognostic model.
Literature analysis confirmed the heterogeneity in 5-year survival rates, partly explained in subsets of homogeneous T-values. The sample included 223 patients, randomly separated into a derivation (n = 141) and a validation set (n = 82). Invasion of the sphenoid lateral and/or posterior walls and dura/cerebral invasion were systematically associated with a poor survival.
The incorporation of the invasion of the sphenoid lateral or posterior walls should be considered for ITAC management and prognostication. © 2017 Wiley Periodicals, Inc. Head Neck 39: 668-678, 2017.