%0 Journal Article
%T Association between serum CA 19-9 and metabolic syndrome: A cross-sectional study.
%A Du R
%A Cheng D
%A Lin L
%A Sun J
%A Peng K
%A Xu Y
%A Xu M
%A Chen Y
%A Bi Y
%A Wang W
%A Lu J
%A Ning G
%J J Diabetes
%V 9
%N 11
%D Nov 2017
%M 28067474
%F 4.53
%R 10.1111/1753-0407.12523
%X <B>BACKGROUND: </B>Increasing evidence suggests that serum CA 19-9 is associated with abnormal glucose metabolism. However, data on the association between CA 19-9 and metabolic syndrome is limited. The aim of the present study was to investigate the association between serum CA 19-9 and metabolic syndrome.<BR><B>METHODS: </B>A cross-sectional study was conducted on 3641 participants aged ≥40 years from the Songnan Community, Baoshan District in Shanghai, China. Logistic regression analysis was used to evaluate the association between serum CA 19-9 and metabolic syndrome.<BR><B>RESULTS: </B>Multivariate logistic regression analysis showed that compared with participants in the first tertile of serum CA 19-9, those in the second and third tertiles had increased odds ratios (OR) for prevalent metabolic syndrome (multivariate adjusted OR 1.46 [95% confidence interval {CI} 1.11-1.92] and 1.51 [95% CI 1.14-1.98]; P trend  = 0.005). In addition, participants with elevated serum CA 19-9 (≥37 U/mL) had an increased risk of prevalent metabolic syndrome compared with those with serum CA 19-9 < 37 U/mL (multivariate adjusted OR 2.10; 95% CI 1.21-3.65).<BR><B>CONCLUSIONS: </B>Serum CA 19-9 is associated with an increased risk of prevalent metabolic syndrome. In order to confirm this association and identify potential mechanisms, prospective cohort and mechanic studies should be performed.