%0 Journal Article
%T Developmental origin of postnatal cardiomyogenic progenitor cells.
%A Liu YH
%A Lai LP
%A Huang SY
%A Lin YS
%A Wu SC
%A Chou CJ
%A Lin JL
%J Future Sci OA
%V 2
%N 2
%D Jun 2016
%M 28031967
暂无%R 10.4155/fsoa-2016-0006
%X <B>OBJECTIVE: </B>To trace the cell origin of the cells involved in postnatal cardiomyogenesis.<BR><B>METHODS: </B>Nkx2.5 enhancer-eGFP (Nkx2.5 enh-eGFP) mice were used to test the cardiomyogenic potential of Nkx2.5 enhancer-expressing cells. By analyzing Cre excision of activated Nkx2.5-eGFP+ cells from different lineage-Cre/Nkx2.5 enh-eGFP/ROSA26 reporter mice, we traced the developmental origin of Nkx2.5 enhancer-expressing cells.<BR><B>RESULTS: </B>Nkx2.5 enhancer-expressing cells could differentiate into striated cardiomyocytes both in vitro and in vivo. Nkx2.5-eGFP+ cells increased remarkably after experimental myocardial infarction (MI). The post-MI Nkx2.5-eGFP+ cells originated from the embryonic epicardial cells, not from the pre-existing cardiomyocytes, endothelial cells, cardiac neural crest cells or perinatal/postnatal epicardial cells.<BR><B>CONCLUSIONS: </B>Postnatal Nkx2.5 enhancer-expressing cells are cardiomyogenic progenitor cells and originate from embryonic epicardium-derived cells.