%0 Journal Article
%T [Immune Tolerance Mediated by TIM-3,LAG-3 and BTLA and Their Reversion in Hematological Malignancies-Review].
%A Chen SH
%A Zha XF
%A Li YQ
%J Zhongguo Shi Yan Xue Ye Xue Za Zhi
%V 24
%N 5
%D Oct 2016
%M 27784399
暂无%R 10.7534/j.issn.1009-2137.2016.05.056
%X The main mechanism of tumor immune suppression is due to the T cell exhaustion which is mediated by abnormal expression of T-cell immunosuppressive receptors in immune cells. Blocking these molecules may restore partial or all functions of T cells. This article reviews the advance on the role of the newly discovered T cell immuno-suppressive receptors such as TIM-3, LAG-3 and BTLA, including their mediated T cell-immune tolerance and the study of targeted immunotherapy in hematological malignancies, so as to provide the new strategy for immune-targeted therapy for hematological malignancies.