%0 Journal Article %T Impact of luteal phase support with vaginal progesterone on the clinical pregnancy rate in intrauterine insemination cycles stimulated with gonadotropins: a randomized multicenter study. %A Peeraer K %A D'Hooghe T %A Laurent P %A Pelckmans S %A Delvigne A %A Laenen A %A Welkenhuysen M %A Wyns C %A De Neubourg D %J Fertil Steril %V 106 %N 6 %D Nov 2016 %M 27565253 %F 7.49 %R 10.1016/j.fertnstert.2016.07.1096 %X OBJECTIVE: To evaluate the effect of luteal phase support (LPS) in intrauterine insemination (IUI) cycles stimulated with gonadotropins.
METHODS: Randomized multicenter trial.
METHODS: Academic tertiary care centers and affiliated secondary care centers.
METHODS: Three hundred and ninety-three normo-ovulatory patients, <43 years, with body mass index ≤30 kg/m2, in their first IUI cycle, with at least one patent tube, a normal uterine cavity, and a male partner with total motile sperm count ≥5 million after capacitation.
METHODS: Gonadotropin stimulation, IUI, randomization to LPS using vaginal progesterone gel (n = 202) or no LPS (n = 191).
METHODS: Clinical pregnancy rate, live-birth rate, miscarriage rate, and duration of the luteal phase.
RESULTS: The primary outcome, the clinical pregnancy rate, was not statistically different between the treatment group (16.8%) and the control group (11%) (relative risk [RR] 1.54; 95% confidence interval [CI], 0.89-2.67). Similarly, the secondary outcome, the live-birth rate, was 14.9% in the treatment group and 9.4% in the control group (RR 1.60; 95% CI, 0.89-2.87). The mean duration of the luteal phase was about 2 days longer in the treatment group (16.6 ± 2.2 days) compared with the control group (14.6 ± 2.5 days) (mean difference 2.07; 95% CI, 1.58-2.56).
CONCLUSIONS: Although a trend toward a higher clinical pregnancy rate as well as live-birth rate was observed in the treatment group, the difference with the control group was not statistically significant.
BACKGROUND: NCT01826747.