%0 Journal Article
%T Association Between Arterial Carbon Dioxide Tension and Outcome in Patients Admitted to the Intensive Care Unit After Coronary Artery Bypass Surgery.
%A Choi JH
%A Lee EH
%A Jang MS
%A Jeong DH
%A Kim MK
%J J Cardiothorac Vasc Anesth
%V 31
%N 1
%D Feb 2017
%M 27546829
%F 2.894
%R 10.1053/j.jvca.2016.05.003
%X <B>OBJECTIVE: </B>The aim of this study was to determine the association between PaCO2 and patient outcome in patients admitted to the intensive care unit (ICU) after coronary artery bypass grafting (CABG).<BR><B>METHODS: </B>A retrospective cohort study.<BR><B>METHODS: </B>Single-institutional, university hospital.<BR><B>METHODS: </B>All patients admitted to the ICU after CABG between January 2009 and December 2012.<BR><B>METHODS: </B>None.<BR><B>RESULTS: </B>Based on PaCO2 status during the first 24 hours after CABG, 1,011 patients were classified into 4 groups: normocapnia, hypocapnia, hypercapnia, and dual hyper/hypocapnia. The 30-day mortality rate was 0.7% (n = 4) for normocapnia, 1.5% (n = 4) for hypocapnia, 2.2% (n = 3) for hypercapnia, and 7.5% (n = 4) for the dual-exposure group. The extubation times were 13.3±21.7 hours, 15.8±21.37 hours, 21.79±39.70 hours, and 42.29±75.35 hours, respectively. After adjusting for confounding variables, the dual hypocapnia and hypercapnia exposure group was associated with increased 30-day mortality (odds ratio [OR] = 8.08; 95% confidence interval [CI], 1.82-35.86; p = 0.006) and delayed extubation (OR = 2.40; 95% CI, 1.24-4.64; p = 0.010).<BR><B>CONCLUSIONS: </B>Exposure to both hypocapnia and hypercapnia within 24 hours after CABG was associated independently with increased risk of 30-day mortality and delayed extubation. Exposure to either hypocapnia or hypercapnia alone was not associated with patient outcome.