%0 Case Reports
%T Marked elevation of urinary β2-microglobulin in patients with reversible splenial lesions: A small case series.
%A Azuma J
%A Nabatame S
%A Katsura T
%A Yamamoto K
%A Kaneno H
%A Kijima E
%A Mizoguchi Y
%A Shimotsuji T
%A Yamamoto T
%A Ozono K
%J J Neurol Sci
%V 368
%N 0
%D Sep 2016 15
%M 27538611
%F 4.553
%R 10.1016/j.jns.2016.06.066
%X The magnetic resonance imaging findings of reversible isolated lesions with transiently reduced diffusion in the splenium of corpus callosum of patients with a wide spectrum of pathological conditions are referred to as reversible splenial lesion syndrome (RESLES). Clinically mild encephalitis/encephalopathy with a reversible splenial lesion (MERS) is probably included within the spectrum of RESLES; however, its exact pathophysiology is not known. Here, we describe three patients with MERS and one patient with RESLES, all of whom showed elevated urinary β2-microglobulin regardless of diagnosis and presence of pathogens. Elevated urinary β2-microglobulin suggested that an excessive immune response might play a role in the pathophysiology of reversible splenial lesions.