%0 Journal Article
%T MiR-22 promotes porcine reproductive and respiratory syndrome virus replication by targeting the host factor HO-1.
%A Xiao S
%A Du T
%A Wang X
%A Ni H
%A Yan Y
%A Li N
%A Zhang C
%A Zhang A
%A Gao J
%A Liu H
%A Pu F
%A Zhang G
%A Zhou EM
%J Vet Microbiol
%V 192
%N 0
%D Aug 2016 30
%M 27527787
%F 3.246
%R 10.1016/j.vetmic.2016.07.026
%X Porcine reproductive and respiratory syndrome virus (PRRSV) is one of the most economically important viruses affecting the swine industry worldwide. MicroRNAs (miRNAs) play vital roles in virus-host interactions by regulating the expression of viral or host gene at posttranscriptional level. Our previous research showed that PRRSV infection down-regulates the expression of heme oxygenase-1 (HO-1), a pivotal cytoprotective enzyme, and overexpression of HO-1 inhibits PRRSV replication. In this study, we demonstrate that host miRNA miR-22 can downregulate HO-1 expression by directly targeting its 3' untranslated region. Suppression of HO-1 expression by miR-22 facilitates PRRSV replication. This work suggests that PRRSV may utilize cellular miRNA to modify antiviral host factor expression, enabling viral replication, which not only provides new insights into virus-host interactions during PRRSV infection, but also suggests potential therapies for PRRSV infection.