%0 Journal Article
%T Hostile takeover: Manipulation of HIF-1 signaling in pathogen-associated cancers (Review).
%A Zhu C
%A Zhu Q
%A Wang C
%A Zhang L
%A Wei F
%A Cai Q
%J Int J Oncol
%V 49
%N 4
%D Oct 2016
%M 27499495
%F 5.884
%R 10.3892/ijo.2016.3633
%X Hypoxia-inducible factor (HIF)-1 is a central regulator in the adaptation process of cell response to hypoxia (low oxygen). Emerging evidence has demonstrated that HIF-1 plays an important role in the development and progression of many types of human diseases, including pathogen-associated cancers. In the present review, we summarize the recent understandings of how human pathogenic agents including viruses, bacteria and parasites deregulate cellular HIF-1 signaling pathway in their associated cancer cells, and highlight the common molecular mechanisms of HIF-1 signaling activated by these pathogenic infection, which could act as potential diagnostic markers and new therapeutic strategies against human infectious cancers.