%0 Journal Article
%T Efficacy of a specific polyclonal equine F(ab')2 against avian influenza (H5N1) in ferrets: synergy with oseltamivir.
%A Herbreteau CH
%A Denizot M
%A Lowther S
%A Riddell S
%A Frazer L
%A Haining J
%A Arkinstall R
%A Payne J
%A Harper J
%A Johnson D
%A Pasquier A
%A Middleton D
%A Saluzzo JF
%J Immunotherapy
%V 8
%N 9
%D 09 2016
%M 27380317
%F 4.04
%R 10.2217/imt-2016-0062
%X Current therapies against avian influenza (H5N1) provide limited clinical benefit. FBF-001 is a highly purified equine polyclonal immunoglobulin fragment against H5N1.<BR>Using a ferret model of severe acute H5N1 infection, we assessed FBF-001 when administered on the same day or 1 day after viral challenge, in comparison with oseltamivir therapy.<BR>Untreated animals died 2-3 days after challenge. FBF-001 prevented most severe illness and reduced nasal viral load, with best efficacy when administered on the day of viral challenge. Oseltamivir and FBF-001 had synergistic impact on survival.<BR>FBF-001 prevented severe consequences of lethal H5N1 challenge in ferrets by controlling viral replication, an effect synergistic to oseltamivir. FBF-001 has recently been granted EMA orphan drug status.