%0 Journal Article
%T A meta-analysis of the diagnostic value of detecting K-ras mutation in pancreatic juice as a molecular marker for pancreatic cancer.
%A Yang J
%A Li S
%A Li J
%A Wang F
%A Chen K
%A Zheng Y
%A Wang J
%A Lu W
%A Zhou Y
%A Yin Q
%A Zhang H
%A Guo C
%J Pancreatology
%V 16
%N 4
%D Jul-Aug 2016
%M 27237100
%F 3.977
%R 10.1016/j.pan.2016.04.033
%X <B>BACKGROUND: </B>K-ras codon 12 mutation is one of the earliest genetic changes in the development of pancreatic cancer (PC) and accurate detection of K-ras mutations is gaining increasing attention in the field of molecular diagnosis.<BR><B>METHODS: </B>Original research articles which evaluated the diagnostic accuracy of K-ras mutation detection in PC were selected. Data were presented as forest plots and summary receiver operating characteristic curve analysis was used to summarize the overall test performance.<BR><B>RESULTS: </B>We assessed 16 studies from 15 published articles. The pooled sensitivity and specificity were 59% (95%CI: 54%-64%) and 87% (95%CI: 84%-89%), respectively. The pooled positive likelihood ratio and negative likelihood ratio were 4.13 (95%CI: 2.73-6.25) and 0.42 (95%CI: 0.32-0.56), respectively, and the pooled diagnostic odds ratio was 13.66 (95% CI: 7.25-25.74).<BR><B>CONCLUSIONS: </B>Our results indicate that the analysis of K-ras mutations in pancreatic juice has a considerable diagnostic value in PC. Further studies with rigorous design, large sample size, and multi-regional co-operation are needed.