%0 Journal Article
%T Scedosporium apiospermum infections and the role of combination antifungal therapy and GM-CSF: A case report and review of the literature.
%A Goldman C
%A Akiyama MJ
%A Torres J
%A Louie E
%A Meehan SA
%J Med Mycol Case Rep
%V 11
%N 0
%D Mar 2016
%M 27182483
暂无%R 10.1016/j.mmcr.2016.04.005
%X Scedosporium apiospermum, a ubiquitous environmental mold, is increasingly reported as causing invasive fungal disease in immunocompromised hosts. It poses a therapeutic challenge due to its intrinsic resistance to traditional antifungals and ability to recur despite demonstrating susceptibility. We present an immunocompromised patient with a cutaneous S. apiospermum infection that disseminated despite treatment with voriconazole, the drug of choice. Adding echinocandins and GM-CSF provided partial recovery, indicating a potential synergistic role of dual-antifungal and immunotherapeutic agents.