%0 Case Reports
%T Recurrent Staphylococcus aureus abscess and fatal pneumococcal septicemia due to IRAK-4 deficiency.
%A Shichijo K
%A Ogose T
%A Kubota M
%A Tomimoto A
%A Kondo R
%A Taniguchi T
%A Takahashi A
%A Nakatsu T
%A Urano Y
%A Watanabe T
%J Pediatr Int
%V 57
%N 6
%D Dec 2015
%M 26711917
%F 1.617
%R 10.1111/ped.12722
%X We describe the case of an infant with recurrent episodes of staphylococcal skin abscess and subsequent lethal pneumococcal meningitis/septicemia due to interleukin-1 receptor-associated kinase 4 (IRAK-4) deficiency. In this case, systemic signs of inflammatory response were poor and delayed. Among all other reported cases of IRAK-4 deficiency, none involved severe viral or fungal disease, and the range of infecting bacteria was narrow.