%0 Journal Article
%T 2-(Nitroaryl)benzothiazole and benzoxazole derivatives as fluorogenic substrates for the detection of nitroreductase activity in clinically important microorganisms.
%A Cellier M
%A Gignoux A
%A James AL
%A Orenga S
%A Perry JD
%A Robinson SN
%A Stanforth SP
%A Turnbull G
%J Bioorg Med Chem Lett
%V 25
%N 24
%D Dec 2015 15
%M 26547691
%F 2.94
%R 10.1016/j.bmcl.2015.10.099
%X A series of carboxy-substituted 2-(nitroaryl)benzothiazole derivatives and carboxy-substituted 2-(nitroaryl)benzoxazole derivatives were prepared and evaluated as potential nitroreductase substrates for the purpose of detecting clinically important microorganisms. Several of the substrates produced highly fluorescent colonies with the majority of a panel of 10 Gram-negative bacteria and also with two of a panel of 8 Gram-positive bacteria.