%0 Journal Article
%T Discovery of a new class of antiviral compounds: camphor imine derivatives.
%A Sokolova AS
%A Yarovaya OI
%A Shernyukov AV
%A Gatilov YV
%A Razumova YV
%A Zarubaev VV
%A Tretiak TS
%A Pokrovsky AG
%A Kiselev OI
%A Salakhutdinov NF
%J Eur J Med Chem
%V 105
%N 0
%D Nov 2015 13
%M 26498572
%F 7.088
%R 10.1016/j.ejmech.2015.10.010
%X A new class of compounds featuring a camphor moiety has been discovered that exhibits potent inhibitory activity against influenza A(H1N1)pdm09 and A(H5N1) viruses. The synthesized compounds were characterized by spectroscopic analysis; in addition the structures of compound 2 and 14 were elucidated by the X-ray diffraction technique. Structure-activity relationship studies have been conducted to identify the 1,7,7-trimethylbicyclo[2.2.1]heptanes2-ylidene group as the key functional group responsible for the observed antiviral activity. The most potent antiviral compound is imine 2 with therapeutic index more than 500.