%0 Case Reports
%T A case of donepezil-related torsades de pointes.
%A Kitt J
%A Irons R
%A Al-Obaidi M
%A Missouris C
%J BMJ Case Rep
%V 2015
%N 0
%D Oct 2015 5
%M 26438681
暂无%R 10.1136/bcr-2015-211900
%X An 80-year-old woman with Alzheimer's dementia presented with diarrhoea, vomiting and worsening confusion following an increase in donepezil dose from 5 to 10 mg. The ECG revealed prolongation of QTc interval. Soon after admission, she became unresponsive with polymorphic ventricular tachycardia (VT). Cardiopulmonary resuscitation with a 200 J shock was successful in establishing cardiac output. Following the discontinuation of donepezil, the QTc interval normalised and no further arrhythmias were recorded. Treatment with anticholinesterase inhibitors may result in life-threatening VT. Vigilance is required for the identification of this condition in patients presenting with presyncope, syncope or seizures.