%0 Case Reports
%T Adenoid ameloblastoma: clinicopathologic description of five cases and systematic review of the current knowledge.
%A Loyola AM
%A Cardoso SV
%A de Faria PR
%A Servato JP
%A Eisenberg AL
%A Dias FL
%A Thavaraj S
%A Gomes CC
%A Gomez RS
%J Oral Surg Oral Med Oral Pathol Oral Radiol
%V 120
%N 3
%D Sep 2015
%M 26297394
暂无%R 10.1016/j.oooo.2015.05.011
%X <B>OBJECTIVE: </B>To describe the clinicopathologic and immunohistochemical features of five cases of adenoid ameloblastoma.<BR><B>METHODS: </B>Clinicopathologic data were gathered from medical records and compared with those compiled from a systematic review. Slides were also immunohistochemically stained for Ki-67, p16, p53, and cytokeratins (7, 8, 14, 18, and 19).<BR><B>RESULTS: </B>There were 3 males (60%) and 2 (40%) females. The mean age was 44 ± 10 years. Of the five adenoid ameloblastomas, 4 (80%) occurred in the posterior maxilla. Patients typically complained of asymptomatic swelling. All patients received surgical resection as primary therapy; 1 (20%) patient also received adjuvant radiotherapy. Recurrence was diagnosed in all patients. Immunohistochemically, the tumors stained focally positive for CK7, 8, 14, and 18 and diffusely positive for CK-19, p16, and p53. The mean Ki-67-positive cells were 72.4 ± 24.9 positive cells per high-power field (range 53-111).<BR><B>CONCLUSIONS: </B>To our knowledge, this is the largest series of adenoid ameloblastoma reported in the literature. Our data suggest that this entity demonstrates aggressive behavior characterized by a high likelihood of recurrence.