%0 Journal Article
%T Efficacy and Safety of Calcipotriol/Betamethasone Dipropionate Ointment for the Treatment of Trachyonychia: An Open-Label Study.
%A Park JM
%A Cho HH
%A Kim WJ
%A Mun JH
%A Song M
%A Kim HS
%A Ko HC
%A Kim BS
%A Kim MB
%J Ann Dermatol
%V 27
%N 4
%D Aug 2015
%M 26273150
%F 0.722
%R 10.5021/ad.2015.27.4.371
%X <B>BACKGROUND: </B>Despite efforts to treat trachyonychia, there is no promising treatment modality.<BR><B>OBJECTIVE: </B>This study evaluated the efficacy and safety of calcipotriol plus betamethasone dipropionate ointment on trachyonychia.<BR><B>METHODS: </B>A total of 39 patients with 432 nails affected by trachyonychia were enrolled. All patients applied calcipotriol/betamethasone ointment once daily without occlusion for 6 months. Outcome measures were assessed by physician's global assessment (degree of roughness: 0, clear; 1, mild; 2, moderate; 3, marked; 4, severe) at all time points.<BR><B>RESULTS: </B>After 6 months of therapy, 98.6% (426/432) of nails showed significant clinical improvement; 4.2% were completely free from nail lesions. The mean physician global assessment score decreased significantly from 3.5 to 1.7 points (p< 0.05). No serious side effects were reported, except mild pruritus and erythema in 2 patients.<BR><B>CONCLUSIONS: </B>This is the first study to prospectively evaluate the efficacy and safety of calcipotriol/betamethasone ointment for the treatment of trachyonychia. The results indicate topical calcipotriol/betamethasone is an effective and safe treatment for symptom improvement of trachyonychia.