%0 Case Reports
%T Cell-free fetal DNA in the maternal circulation originates from the cytotrophoblast: proof from an unique case.
%A Hochstenbach R
%A Nikkels PG
%A Elferink MG
%A Oudijk MA
%A van Oppen C
%A van Zon P
%A van Harssel J
%A Schuring-Blom H
%A Page-Christiaens GC
%J Clin Case Rep
%V 3
%N 6
%D Jun 2015
%M 26185654
暂无%R 10.1002/ccr3.285
%X Noninvasive prenatal testing (NIPT) and direct karyotyping of cytotrophoblast were normal for a male fetus, but cultured chorionic villus mesenchymal cells and umbilical cord fibroblasts showed nonmosaic trisomy 18. This observation provides direct evidence for the cytotrophoblastic origin of cell-free fetal DNA and yields a biological explanation for falsely reassuring NIPT results.