%0 Journal Article
%T Antigenic heterogeneity in granular cell ameloblastoma: an immunohistochemical study.
%A Ramya R
%A Sudheerkanth PK
%A Eapen C
%A Alex VK
%A Rajkumar K
%A Rajashree P
%J J Int Oral Health
%V 7
%N 3
%D Mar 2015
%M 25878479
暂无%R 
%X <B>BACKGROUND: </B>Nature of granular cells in granular cell ameloblastoma (GCA) has always invoked considerable interest. The present study aims at antigenic characterization in five such cases with a panel of markers.<BR><B>METHODS: </B>Tissue specimens of five patients with GCA were fixed in buffered formalin and later embedded in paraffin wax. Blocks were sliced into 3 µ thick sections for immunohistochemical analysis using a panel of markers CD68, Bcl2, S100, p53, cytokeratin (AE1/AE3), vimentin and desmin.<BR><B>RESULTS: </B>All five cases were strongly positive for cytokeratin and CD68. S100 was negative in three cases and showed a mild positivity in two cases. Bcl2, p53, vimentin and desmin were negative in all the five cases.<BR><B>CONCLUSIONS: </B>This study presents a heterogenous nature of the granular cells; however, further validation is required with a larger sample size.