%0 Journal Article
%T The topological pressure-temperature phase diagram of ritonavir, an extraordinary case of crystalline dimorphism.
%A Céolin R
%A Rietveld IB
%J Ann Pharm Fr
%V 73
%N 1
%D Jan 2015
%M 25496722
暂无%R 10.1016/j.pharma.2014.09.003
%X A topological pressure-temperature phase diagram involving the phase relationships of ritonavir forms I and II has been constructed using experimental calorimetric and volumetric data available from the literature. The triple point I-II-liquid is located at a temperature of about 407 K and a pressure as extraordinarily small as 17.5 MPa (175 bar). Thus, the less soluble solid phase (form II) will become metastable on increasing pressure. At room temperature, form I becomes stable around 100 MPa indicating that form II may turn into form I at a relatively low pressure of 1000 bar, which may occur under processing conditions such as mixing or grinding. This case is a good example for which a proper thermodynamic evaluation trumps "rules of thumb" such as the density rule.