%0 Journal Article
%T Dysplastic nevi, cutaneous melanoma, and other skin neoplasms in patients with myotonic dystrophy type 1: a cross-sectional study.
%A Zampetti A
%A Silvestri G
%A Manco S
%A Khamis K
%A Masciullo M
%A Bianchi ML
%A Damiani A
%A Santoro M
%A Linder D
%A Bewley A
%A Feliciani C
%J J Am Acad Dermatol
%V 72
%N 1
%D Jan 2015
%M 25440959
%F 15.487
%R 10.1016/j.jaad.2014.09.038
%X <B>BACKGROUND: </B>Myotonic dystrophy type 1 (MD1) is reported to be associated with internal malignancies. The association of myotonic dystrophy with cutaneous tumors is not fully understood.<BR><B>OBJECTIVE: </B>We sought to explore the total nevi count and the presence of atypical nevi, cutaneous melanoma, and other skin neoplasms in a representative cohort of patients with MD1 and to compare the findings with age- and sex-matched control subjects.<BR><B>METHODS: </B>In all, 90 patients with MD1 and 103 age- and sex-matched control subjects were assessed for cutaneous neoplasms by clinical skin and epiluminescence examination (dermoscopy). Where indicated, subsequent excisions were performed. In patients with MD1, leukocyte n(CTG) expansion was measured.<BR><B>RESULTS: </B>Patients with MD1 showed significantly higher numbers of nevi, dysplastic nevi, and melanomas despite a significantly greater proportion of the control subjects reporting sunburns. In addition, we found a significantly greater number of pilomatrixoma in patients with MD1.<BR><B>CONCLUSIONS: </B>Our study is limited by the fact that there is no agreed-upon standardized technique to assess for prior sun exposure. Further research in the association of cutaneous neoplasms and MD1 including vitamin D and molecular biological techniques are also recommended.<BR><B>CONCLUSIONS: </B>MD1 itself may predispose to development of skin tumors.