%0 Journal Article
%T Distinct factors bind the AP-1 consensus sites in gibbon ape leukemia virus and simian virus 40 enhancers.
%A Quinn JP
%A Takimoto M
%A Iadarola M
%A Holbrook N
%A Levens D
%J J Virol
%V 63
%N 4
%D Apr 1989
%M 2538654
%F 6.549
%R 10.1128/JVI.63.4.1737-1742.1989
%X We have demonstrated that the gibbon ape leukemia virus (GALV) enhancer AP-1 element and the simian virus 40 AP-1 enhancer element bind different factors in HeLa nuclear extracts. A 39-kilodalton HeLa nuclear protein and the c-fos protein bind to the GALV element. Antibodies to c-fos abolish binding to the GALV AP-1 site. In contrast, anti-c-fos immunoglobulin fails to inhibit formation of the simian virus 40-specific complex from extracts of HeLa cells. Thus, AP-1-binding complexes are subject to compositional variation at different binding sites.