%0 Journal Article
%T A review of methods to synthesise 4'-substituted nucleosides.
%A Betson M
%A Allanson N
%A Wainwright P
%J Org Biomol Chem
%V 12
%N 46
%D Dec 2014 14
%M 25302570
%F 3.89
%R 10.1039/c4ob01449a
%X Modified nucleosides have received a great deal of attention from the scientific community, either for use as therapeutic agents, diagnostic tools, or as molecular probes. Perhaps the most difficult position of a nucleoside to modify is the 4'-position. Chemists have developed innovative methods to achieve this in a stereoselective manner to allow incorporation of a variety of functional groups. This review provides a summary of the most commonly used or recently published methods for ribose, deoxy-ribose, 4'-thioribose, and carbocyclics.