%0 Journal Article
%T Hyperactivated Signaling Pathways of Chemokine RANTES/CCL5 in Osteopathies of Jawbone in Breast Cancer Patients-Case Report and Research.
%A Lechner J
%A von Baehr V
%J Breast Cancer (Auckl)
%V 8
%N 0
%D 2014
%M 24899812
暂无%R 10.4137/BCBCR.S15119
%X <B>BACKGROUND: </B>Hollow spaces in the jawbone have been defined as fatty degenerative osteonecrosis of jawbone (FDOJ) and have been linked with a dysregulated immune system. Little is known about the underlying relationship.<BR><B>OBJECTIVE: </B>Samples of FDOJ were analyzed to assess expression of cytokines which can play a role in the pathogenesis of breast cancer (MaCa).<BR><B>METHODS: </B>Samples of FDOJ extracted from 23 patients with MaCa and 19 healthy control jawbone samples were analyzed for 7 immune messengers.<BR><B>RESULTS: </B>RANTES was found to be highly overexpressed in disease samples. No change was observed in expression levels of the other immune mediators.<BR><B>CONCLUSIONS: </B>This data provides a compelling confirmation that FDOJ produces high levels of RANTES, a cytokine implicated in MaCa and metastasis. Levels detected in FDOJ are five-fold higher than that previously reported for MaCa tissue suggesting its role as a cytokine source in MaCa.<BR><B>CONCLUSIONS: </B>We thus hypothesize that FDOJ may serve as an expeditor of MaCa progression, through RANTES production.