%0 Comparative Study
%T Characteristics and natural history of patients with colorectal cancer complicated by infectious endocarditis. Case control study of 25 patients.
%A Ouaïssi M
%A Studer AS
%A Mege D
%A Thuny F
%A Boiron L
%A Loundou A
%A Pirrò N
%A Hamed S
%A Frasconi C
%A Habib G
%A Fournier PE
%A Collart F
%A Sielezneff I
%A Sastre B
%J Anticancer Res
%V 34
%N 1
%D Jan 2014
%M 24403486
%F 2.435
%R 
%X Association between streptococcal endocarditis and gastrointestinal disease has been well-documented in the literature. However oncological impact of this complicated presentation has not yet been reported. We have conducted to our knowledgethe first case-control study on this subject.<BR><B>METHODS: </B>Two groups of five patients with colorectal cancer and either active endocarditis (CRC E+), or without endocarditis (CRC, n=20) were matched 1:4 for age, sex, and location of colorectal tumor.<BR><B>RESULTS: </B>All 25 patients were male, with a median age of 63 (range: 53-85) years. Twenty (80%) had colon cancer and 5 (20%) rectal cancer. There was no post-operative mortality in this population. The overall morbidity was 28% (n=7). The overall 3-year survival and recurrence rates were similar in both groups 80% and 95%; 0% and 30% for group CRC E+ and CRC (p=0.4603).<BR><B>CONCLUSIONS: </B>This is the first case-control study demonstrating that during the first two years of follow-up, occurrence of endocarditis did not alter the prognosis of patients with CRC.