%0 Consensus Development Conference %T Identifying and addressing unmet clinical needs in Ph-neg classical myeloproliferative neoplasms: a consensus-based SIE, SIES, GITMO position paper. %A Barosi G %A Vannucchi AM %A De Stefano V %A Pane F %A Passamonti F %A Rambaldi A %A Saglio G %A Barbui T %A Tura S %J Leuk Res %V 38 %N 2 %D Feb 2014 %M 24378116 %F 3.715 %R 10.1016/j.leukres.2013.09.008 %X This article presents the results of group discussion among experts from SIE, SIES and GITMO societies aimed at highlighting unmet challenges in the management of Ph-neg myeloproliferative neoplasms (MPNs). The issues analyzed were: diagnosis of prefibrotic myelofibrosis; diagnosis of Ph-neg MPNs in the setting of splanchnic vein thrombosis (SVT); management of low-risk PV and low-risk ET patients with JAK2V617F mutation; molecular biomarkers in the prognostic evaluation of myelofibrosis (MF); ruxolitinib therapy in low-risk MF; therapy in patients with SVT-associated Ph-neg MPN; indications of splenectomy in MF. For each of these issues, proposals for advancement in clinical research were addressed.