%0 Case Reports
%T Verrucous hemangioma with pseudoepitheliomatous epidermal hyperplasia in an adult horse.
%A Pérez-Écija A
%A Estepa JC
%A Barranco I
%A Rodríguez-Gómez IM
%A Mendoza FJ
%A Gómez-Laguna J
%J Vet Pathol
%V 51
%N 5
%D Sep 2014
%M 24284263
%F 3.157
%R 10.1177/0300985813513039
%X Verrucous hemangiomas are a rare specific variant of equine skin tumors not well described in the literature. An 8-year-old gelding presented a unilateral lesion on the pastern. Macroscopically, the mass showed a warty and verrucous surface with focal ulcerations. The histology showed a dermal proliferation of endothelial-layered capillaries and venules separated by a delicate stroma of scant fibroblasts and collagen deposition, with pseudoepitheliomatous hyperplasia (exuberant reactive irregular epithelial hyperplasia with tongue-like projections extending into the dermis, mimicking downgrowth of squamous cell carcinoma) and orthokeratotic hyperkeratosis of the overlying epidermis. The immunohistochemical study confirmed the endothelial origin of the tumor, and a final diagnosis of verrucous hemangioma with pseudoepitheliomatous hyperplasia was confirmed. To the knowledge of the authors, this is the first detailed description of this entity in adult horses. Moreover, the clinical progression and epidermal changes have not been previously reported, emphasizing the importance of a pathological study of any epithelial preneoplastic lesion to rule out an underlying dermal neoplasia.