%0 Journal Article
%T Adverse effects of diisooctyl phthalate on the male rat reproductive development following prenatal exposure.
%A Saillenfait AM
%A Sabaté JP
%A Robert A
%A Cossec B
%A Roudot AC
%A Denis F
%A Burgart M
%J Reprod Toxicol
%V 42
%N 0
%D Dec 2013
%M 24055997
%F 3.421
%R 10.1016/j.reprotox.2013.09.004
%X In a first study, rats were given diisooctyl phthalate (DIOP, CAS 27554-26-3) at 0, 0.1, 0.5, and 1g/kg/day, by gavage, on gestation days 6-20 (GD). There was a significant increase in resorptions at 1g/kg/day and a reduction in fetal weights at 0.5 and 1g/kg/day. Malpositioned testes were observed in fetuses at 1g/kg/day, and supernumerary lumbar ribs and ossification delay at 0.5 and 1g/kg/day. In a follow-up study, DIOP administered on GD 12-19 reduced fetal testicular testosterone at 0.1g/kg/day and above. Finally, postnatal reproductive assessment was conducted in adult male offspring prenatally exposed to DIOP on GD 12-21. Abnormalities of reproductive system (e.g. hypospadias, non scrotal testes, and hypospermatogenesis) were observed in a few adult males at 0.5g/kg/day, and with a high incidence at 1g/kg/day. Thus, DIOP displayed an antiandrogenic activity and disrupted the male reproductive development.