%0 Journal Article
%T Quantum chemistry as a tool in asymmetric biocatalysis: limonene epoxide hydrolase test case.
%A Lind ME
%A Himo F
%J Angew Chem Int Ed Engl
%V 52
%N 17
%D Apr 2013 22
%M 23512539
%F 16.823
%R 10.1002/anie.201300594
%X Cluster model: Large active-site models (see figure) are used to investigate the selectivity of limonene epoxide hydrolase, both the wild type and mutants optimized through directed evolution. Good agreement is found between theory and the experimental data, thus demonstrating that the quantum chemical cluster approach can be a powerful tool in the field of asymmetric biocatalysis.