%0 Journal Article
%T Metformin: a case of divide and conquer.
%A Anastasiou D
%J Breast Cancer Res
%V 15
%N 2
%D Mar 2013 11
%M 23510106
%F 8.408
%R 10.1186/bcr3387
%X Metformin is a widely prescribed anti-diabetic drug and its use is associated with lower cancer incidence. The mechanisms by which metformin attenuates tumorigenesis are not clearly understood. In a paper published in Proceedings of the National Academy of Sciences of the United States of America, Hirsch and colleagues show that metformin interferes with a signaling pathway, mediated by the transcription factor NF-κB, which drives cell transformation and is required for the maintenance of cancer stem cells.