%0 Journal Article
%T Influence of alcohol consumption on oxidative stress and antioxidant status in cancer patients--case-control study from Western Nepal.
%A Nagamma T
%A Bhutia RD
%A Pokharel DR
%A Yadav S
%A Baxi J
%J Asian Pac J Cancer Prev
%V 13
%N 7
%D 2012
%M 22994787
暂无%R 10.7314/apjcp.2012.13.7.3513
%X <B>OBJECTIVE: </B>The present study assess the effect of consumption of alcohol on oxidative stress and antioxidant status in patients suffering from different types of cancer.<BR><B>METHODS: </B>This hospital based case control study conducted in the Western part of Nepal covered a total of 93 cancer patients with or without alcohol intake and smoking habits, along with 94 age, sex and habit-matched individuals serving as controls. Plasma thiobarbituric acid reacting substances (TBARS), total antioxidant activity (TAA), vitamin C, α-tocopherol and erythrocyte reduced glutathione (GSH) were estimated and compared.<BR><B>RESULTS: </B>The TBARS level was found to be significantly higher (p≤0.001) in all types of cancer patients when compared to controls, being aggravated in alcoholics with a smoking habit. No statistical significance (p≥0.05) was observed in the level of vitamin C and α-tocopherol. GSH and TAA level were significantly decreased (p≤0.001) in all the groups except those who consumed both branded as well as homemade alcohol and non-alcoholics without smoking habit.<BR><B>CONCLUSIONS: </B>Alcohol, irrespective of its commercial brand, increases oxidative stress in all types of cancer patients. This is even higher when alcohol intake is combined with a smoking habit. Decreased TAA and GSH are major risk factors for cancer development.