%0 Journal Article
%T National Institute on Aging-Alzheimer's Association guidelines for the neuropathologic assessment of Alzheimer's disease: a practical approach.
%A Montine TJ
%A Phelps CH
%A Beach TG
%A Bigio EH
%A Cairns NJ
%A Dickson DW
%A Duyckaerts C
%A Frosch MP
%A Masliah E
%A Mirra SS
%A Nelson PT
%A Schneider JA
%A Thal DR
%A Trojanowski JQ
%A Vinters HV
%A Hyman BT
%A  
%A  
%J Acta Neuropathol
%V 123
%N 1
%D Jan 2012
%M 22101365
%F 15.887
%R 10.1007/s00401-011-0910-3
%X We present a practical guide for the implementation of recently revised National Institute on Aging-Alzheimer's Association guidelines for the neuropathologic assessment of Alzheimer's disease (AD). Major revisions from previous consensus criteria are: (1) recognition that AD neuropathologic changes may occur in the apparent absence of cognitive impairment, (2) an "ABC" score for AD neuropathologic change that incorporates histopathologic assessments of amyloid β deposits (A), staging of neurofibrillary tangles (B), and scoring of neuritic plaques (C), and (3) more detailed approaches for assessing commonly co-morbid conditions such as Lewy body disease, vascular brain injury, hippocampal sclerosis, and TAR DNA binding protein (TDP)-43 immunoreactive inclusions. Recommendations also are made for the minimum sampling of brain, preferred staining methods with acceptable alternatives, reporting of results, and clinico-pathologic correlations.