%0 Journal Article
%T Receptor nomenclature guidelines.
%A Williams M
%J Curr Protoc Pharmacol
%V 0
%N 0
%D May 2001
%M 21965062
暂无%R 10.1002/0471141755.pha01bs06
%X Receptors are typically characterized via two distinct approaches: (1) the identification and pharmacological characterization of a receptor-mediated response using classical pharmacological and/or radioligand approaches in tissues and animal models using selective agonist and antagonist ligands, and; (2) the cloning and expression of proteins with structural homology to known receptors, the function of which is subsequently established by studying the structure activity relationship (SAR) of receptor-mediated responses. An additional means to characterize receptors proceeded, and evolved, with the structural approach, namely classification in terms of signal transduction mechanisms. The International Union of Pharmacology (IUPHAR) created guidelines and selected working groups for each receptor family to establish a common nomenclature system. Reports from those groups that have reached some degree of consensus have been summarized in this appendix.