%0 Journal Article
%T A review of ERGIC-53: its structure, functions, regulation and relations with diseases.
%A Zhang YC
%A Zhou Y
%A Yang CZ
%A Xiong DS
%J Histol Histopathol
%V 24
%N 9
%D 09 2009
%M 19609866
%F 2.13
%R 10.14670/HH-24.1193
%X ERGIC-53 is a type I transmembrane protein. It includes an N-terminal signal sequence, a carbohydrate recognition domain, which is calcium-dependent and pH-sensitive, a stalk region, a transmembrane domain, and a short cytoplasmic domain; ERGIC-53 mainly acts as a receptor of a limited number of glycoprotein and transports them from ER to ERGIC and Golgi, meanwhile it has a secondary glycoprotein quality control function. Recent research has revealed that UPR, heat shock and VIPL may regulate the expression of ERGIC-53. F5F8D, and some ER storage diseases have relationship with ERGIC-53.