%0 Journal Article
%T Toward a consensus on the operation of receptor-induced calcium entry signals.
%A Gill DL
%A Patterson RL
%J Sci STKE
%V 2004
%N 243
%D Jul 2004 20
%M 15280581
暂无%R 10.1126/stke.2432004pe39
%X Receptor-induced Ca2+ signals involve both Ca2+ release from intracellular stores and extracellular Ca2+ entry across the plasma membrane. The channels mediating Ca2+ entry and the mechanisms controlling their function remain largely a mystery. Here we critically assess current views on the Ca2+ entry process and consider certain modifications to the widely held hypothesis that Ca2+ store emptying is the fundamental trigger for receptor-induced Ca2+ entry channels. Under physiological conditions, receptor-induced store depletion may be quite limited. A number of distinct channel activities appear to mediate receptor-induced Ca2+ entry, and their activation is observed to occur through quite diverse coupling processes.