%0 Case Reports
%T Treatment of primary limited cutaneous extramammary Paget's disease with topical imiquimod monotherapy: two case reports.
%A Zampogna JC
%A Flowers FP
%A Roth WI
%A Hassenein AM
%J J Am Acad Dermatol
%V 47
%N 4
%D Oct 2002
%M 12271284
%F 15.487
%R 10.1067/mjd.2002.126584
%X We present two cases of primary limited cutaneous perineal and genital extramammary Paget's disease (EMPD) that were successfully treated with imiquimod 5% cream. Clinical and histologic cure was confirmed after 7.5 to 12 weeks of monotherapy. Treatment-associated morbidity is minimal compared with more invasive therapies, and self-application by the patient improves convenience and appeal. Imiquimod may offer a minimally invasive and promising therapeutic option for the treatment of limited cutaneous EMPD. The diagnosis and management of EMPD and the current literature regarding imiquimod therapy are reviewed.