%0 Journal Article
%T Guidelines for the safe administration of high-dose interleukin-2.
%A Schwartzentruber DJ
%J J Immunother
%V 24
%N 4
%D Jul-Aug 2001
%M 11565830
%F 4.912
%R 10.1097/00002371-200107000-00004
%X High-dose interleukin-2 (IL-2) results in objective clinical regression of metastatic cancer in 15% to 17% of patients with melanoma and renal cell carcinoma. Durable complete regression of all metastases is seen in 6% to 8% of patients. Based on these findings, the U.S. Food and Drug Administration has approved the use of high-dose IL-2 for the treatment of patients with metastatic melanoma and renal cell carcinoma. Interleukin-2 administration is associated with many different side effects, and after many years of use, clinicians have learned how to safely administer high-dose IL-2. This article details practical guidelines for the safe administration of high-dose IL-2.