%0 Comparative Study
%T GAR-936 (9-t-butylglycylamido-minocycline) susceptibility test development for streptococci, Haemophilus influenzae and Neisseria gonorrhoeae: preliminary guidelines and interpretive criteria.
%A Deshpande LM
%A Gales AC
%A Jones RN
%J Int J Antimicrob Agents
%V 18
%N 1
%D Jul 2001
%M 11463523
%F 15.441
%R 10.1016/s0924-8579(01)00355-7
%X GAR-936, a new semisynthetic derivative of minocycline, has earlier shown promising activity against tetracycline-resistant pathogens, including Streptococcus pneumoniae. In this study, the activity of GAR-936 was tested against a total of 514 tetracycline-susceptible and -resistant strains of S. pneumoniae, beta-haemolytic streptococci, viridans group streptococci, Haemophilus influenzae and Neisseria gonorrhoeae. All strains of H. influenzae, were inhibited by < or =2 mg/l of GAR-936, with MIC(90)s for all streptococci and gonococci of < or =0.5 mg/l. Scattergrams of GAR-936 comparing MICs by broth microdilution testing and zone diameters using 30 microg disks, confirmed the proposed susceptibility criteria of < or 2 mg/l or > or =20 mm zone diameter. Clinical trial results should be correlated with these preliminary in vitro results to confirm and/or adjust these susceptibility interpretive criteria for GAR-936 when testing fastidious streptococci, H. influenzae and N. gonorrhoeae.