PDF(Pubmed)
Abstract：
Systemic inflammatory response index (SIRI) has been proven to be associated with the prognosis of coronary artery disease and many other diseases. However, the relationship between SIRI and acute traumatic spinal cord injury (tSCI) has rarely been evaluated. The study aims to assess the prognostic value of SIRI for clinical outcomes in individuals with acute tSCI. A total of 190 patients admitted within eight hours after tSCI between January 2021 and April 2023 were enrolled in our study. Logistic regression analysis was used to analyze the association between SIRI and American Spinal Injury Association Impairment Scale (AIS) grade at admission and discharge, as well as neurological improvement in tSCI patients, and receiver operating characteristic (ROC) analysis was performed to assess the discriminative ability of SIRI in predicting AIS grade at discharge. After adjusting for confounding factors, SIRI positively correlated with the AIS grade (A to C) at admission and discharge, and negatively correlated with neurological improvement. The area under the curve values in ROC analysis was 0.725 (95% CI 0.647, 0.803). The study suggests that SIRI is significantly associated with an increased risk of poor clinical outcome at discharge in tSCI patients and has a certain discriminative value.
摘要：
全身炎症反应指数（SIRI）已被证明与冠状动脉疾病和许多其他疾病的预后有关。然而,SIRI与急性创伤性脊髓损伤(tSCI)之间的关系很少被评估.该研究旨在评估SIRI对急性tSCI患者临床结局的预后价值。我们的研究纳入了2021年1月至2023年4月tSCI后8小时内收治的190名患者。采用Logistic回归分析SIRI与入院及出院时美国脊髓损伤协会损伤量表(AIS)分级的相关性,以及tSCI患者的神经系统改善，并进行了受试者工作特征（ROC）分析，以评估SIRI在预测出院时AIS等级的判别能力。在调整混杂因素后，SIRI与入院和出院时的AIS等级(A至C)呈正相关，与神经系统改善呈负相关。ROC分析曲线下面积值为0.725(95%CI0.647,0.803)。该研究表明，SIRI与tSCI患者出院时不良临床结局的风险增加显着相关，并具有一定的鉴别价值。
