Abstract：
The swelling and collapse of responsive nanogels on a planar lipid bilayer are studied by means of mesoscopic computer simulations. The effects of molecular weight, cross-linking density, and adhesion strength are examined. The conditions for collapse-mediated engulfing by the bilayer are found. In particular, the results show that at low hydrophobicity level the increase in the nanogel softness decreases the engulfing rate. On the contrary, for stronger hydrophobicity level the trend changes to the opposite one. At the same time, when the cross-linking density is too low or the adhesion strength is too high the nanogel deformation at the membrane suppresses the engulfing regardless of the network swelling ratio. Finally, for comparative reasons, the behavior of the nanogels is also studied at the solid surface. These results may be useful in the design of soft particles capable of tuning of their elasticity and porosity for successful intracellular drug delivery.
摘要：
通过介观计算机模拟研究了响应性纳米凝胶在平面脂质双层上的溶胀和塌陷。分子量的影响，交联密度，并检查粘合强度。发现了由双层介导的塌陷吞噬的条件。特别是,结果表明，在低疏水性水平下，纳米凝胶柔软度的增加降低了吞噬速率。相反,对于更强的疏水性水平，趋势向相反的方向变化。同时,当交联密度太低或粘合强度太高时,膜处的纳米凝胶变形抑制吞噬,而与网络溶胀率无关。最后,出于比较原因，纳米凝胶的行为也在固体表面进行了研究。这些结果可用于设计能够调节其弹性和孔隙率以成功进行细胞内药物递送的软颗粒。
